Browsing by Author "Bostancı, Hayrani Eren"
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Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
Işık, Ayşen; Çevik, Ulviye Acar; Çelik, İsmail; Bostancı, Hayrani Eren; Karayel, Arzu; Gündoğdu, Gülsüm; İnce, Ufuk; Koçak, Ahmet; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Elsevier, 14.08.2022)Based on the biologically active heterocycle compounds, a series of new benzimidazole-hydrazone deriva- tives ( 3a-3j ) were synthesized, starting from 4-(6-chloro-1 H -benzimidazol-2-yl) benzohydrazide. The syn- thesized ... -
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects
Küçükoğlu, Kaan; Çevik, Ulviye Acar; Nadaroğlu, Hayrunnisa; Çelik, İsmail; Işık, Ayşen; Bostancı, Hayrani Eren; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Medicinal Chemistry Research, 08.08.2022)In this study, eleven new compounds with a series of benzimidazole-1,3,4-oxadiazole derivatives structures were synthesized and evaluated for their human (h) carbonic anhydrase inhibitory activities against two isoforms ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
Bostancı, Hayrani Eren; Bilgiçli, Ahmet Turgut; Güzel, Emre; Günsel, Armağan; Hepokur, Ceylan; Çimen, Behzat; Yaraşır, Meryem Nilüfer (Royal Society of Chemistry, 21.09.2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its nonperipheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
Güncel Uygulanan Kanser Tedavi Yöntemleri
Bostancı, Hayrani Eren (Bilgin Kültür Sanat Yayınları, 25.12.2022)Modern tıp her ne kadar ilerlemiş olsa da kanser için hastalık görülmeden önce ortaya çıkarılması ve erken safhada önlenmesi hala çok önemlidir. Kansere karşı koruyucu olarak; en büyük nedenlerinden biri olan sigara ve ... -
Synthesis, and docking studies of novel tetrazole S-alkyl derivatives as antimicrobial agents
Çevik, Ulviye Acar; Çelik, İsmail; Işık, Ayşen; Gül, Ülküye Dudu; Bayazıt, Gizem; Bostancı, Hayrani Eren; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis, 01.09.2022)A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their antifungal activity against C. albicans (ATCC 24433), C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019) and ... -
Synthesis, Molecular Docking, Dynamics, Quantum-Chemical Computation, and Antimicrobial Activity Studies of Some New Benzimidazole−Thiadiazole Hybrids
Çelik, İsmail; Çevik, Ulviye Acar; Karayel, Arzu; Işık, Ayşen; Kayış, Uğur; Gül, Ülküye Dudu; Bostancı, Hayrani Eren; Konca, Süheyl Furkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (ACS, 09.11.2022)In this study, some new compounds, which are 2aminothiadiazole derivatives linked by a phenyl bridge to the 2position of the benzimidazole ring, were designed and synthesized as antimicrobial agents. The structures of ...